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Video

Rhinology/Allergy

(A1127) Ki67 Index as a Prognosis Predictor in Olfactory Neuroblastoma

Monday, October 13, 2025
12:00 PM - 1:00 PM EDT
Location: OTO EXPO, Posters

    Presenting Author(s)

  • Xiaole Song, MD

    Director of Mucosal Melanoma Diagnosis and Treatment Center
    Eye& ENT Hospital, Fudan University/University of Pennsylvania
    Shanghai, Pennsylvania, United States

    • Co-Author(s)

  • Jingyi Yang, MD

    Attending physician
    Olfactory Neuroblastoma Diagnosis and Treatment Center, Eye& ENT Hospital, Fudan University
    Shanghai, Shanghai, China (People's Republic)

  • Xicai sun, MD, PhD

    Director of Olfactory Neuroblastoma Diagnosis and Treatment Center
    Eye& ENT Hospital, Fudan University
    Shanghai, United States

    • Senior Author(s)

  • HY

    Hongmeng Yu, PhD,MD

    Prof
    Eye& ENT Hospital, Fudan University, United States

Disclosure(s):
Xiaole Song, MD: No relevant relationships to disclose.
Jingyi Yang, MD: No relevant relationships to disclose.
Xicai sun, MD, PhD: No relevant relationships to disclose.


Introduction: Olfactory neuroblastoma (ONB) is a rare, malignant tumor originating from the olfactory neuroepithelial mucosa. Ki67 is an antigen representing proliferation. The relatively small sample size makes it difficult to determine the Ki67 index cutoff value for survival analysis.

Methods: Patients pathologically diagnosed with ONB and treated with surgery and radiotherapy were included. Predictive values of Ki67, S100, and other parameters were determined using receiver operating characteristic (ROC) curves. The correlation between expression levels and overall survival (OS) rates were analyzed. A Cox regression model was used in multivariate analysis.

Results: All 98 patients underwent endoscopic surgery; the average follow-up period was 45.2 ±28.2 months, and the 5-year OS rate was 85.3%. The ROC curve of Ki67 showed a cutoff value of 47.5% (AUC=0.705). The 5-year OS rate in patients with a Ki67 index < 47.5% was significantly higher than that in those with a high (≥47.5%) Ki67 index (91.8% vs. 79.1%, P=0.048). Modified Kadish stage and gross total resection were also factors influencing OS (P=0.004 and P=0.004, respectively). Perioperative complications were associated with poor OS (P=0.006). Multivariate Cox analysis revealed that Ki67 (P=0.044) was an independent predictor of OS. Patients with a high Ki67 index and an S100-negative profile had lower OS rates.

Conclusions: Ki67 index, with a cutoff value of 47.5%, can independently predict OS in ONB. Modified Kadish stage, perioperative complications, and gross total resection were also factors affecting OS in ONB. Patients with a high Ki67 index and an S100-negative profile had poor prognoses and may benefit from chemotherapy.