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Video

Laryngology/Broncho-Esophagology

(A725) Neurogenic Cough: Overview

Monday, October 13, 2025
12:00 PM - 1:00 PM EDT
Location: OTO EXPO, Posters

    Senior Author(s)

  • IO

    Imran Ozdemir, MD

    Usküdar University, Medical Faculty, United States

    • Co-Author(s)

  • Nuray Bayar Muluk, MD

    Professor
    Kirikkale University, Medical Faculty, Department of Otorhinolaryngology
    Ankara, Ankara, Turkey

    • Presenting Author(s)

  • CC

    Cemal Cingi, MD

    Professor
    Eskisehir Osmangazi University
    Eskisehir, United States

Disclosure(s):
Nuray Bayar Muluk, MD: No relevant relationships to disclose.
Cemal Cingi, MD: No relevant relationships to disclose.


Introduction: While hypersensitivity to other cough stimuli, such as in an irritable larynx, can lead to neurogenic cough (1,2), when it occurs on its own, it is usually associated with sensory neuropathy (3). Although sensory neuropathy is typically associated with decreased nerve sensitivity, neurogenic cough manifests clinically as a hyperexcitable disease, which is at odds with the common perception.
Because viral infections are a common cause of isolated idiopathic neurogenic cough, it is essential to consider the signs and processes of laryngeal and other virally-induced nerve injuries. Several conditions in otolaryngology have significant anecdotal evidence linking them to viruses, including idiopathic voice paralysis, vestibular neuronitis, facial palsy, and sudden sensorineural hearing loss. Epidemic viruses, cytomegalovirus, herpes simplex virus, varicella-zoster, and HIV are all known to be associated with this.

Methods: We searched Pubmed, Google, Google Scholar, and EBSCO Academic Search Ultimate (EKUAL) database of Kırıkkale University Library from current time to the past (from 2025 to 1995) with the keywords of “Neurogenic Cough”, Randomized and/or placebo-controlled studies, review papers, metaanalysis, reports are taken into consideration.

Results: The results were reviewed.

Conclusions: Among patients whose cough continued despite proton pump inhibitor treatment, In research that involved medically refractory chronic cough patients, 88% of those who received therapy (patient education, cough control techniques, vocal hygiene, counseling) reported an improvement in their cough. Still, 13% of those who received a placebo (healthy lifestyle education) reported the same progress. In addition, individuals who were medically refractory to cough medication showed improvements in cough-specific quality of life, reduced cough frequency as determined by an objective cough monitor, reduced sensitivity to cough reflexes, and higher threshold to capsaicin exposure after four therapy visits.