Diagnostic Accuracy in Ultrasound-guided Thyroid FNA: Comparative Evaluation of Cytolyt Versus Formalin Smear Techniques

Sunday, October 12, 2025

2:42 PM - 2:48 PM EDT

Location: 128

Disclosure(s):

Haia Darawshe, MD:

faculty for this accredited education activity has no relationship(s) with ineligible companies to disclose.

Introduction: The accuracy of Thyroid fine needle aspiration (FNA) is significantly influenced by the technique employed for preparing and examining the aspirated cells.
This study compares two prevalent techniques for cell smearing - the Cytolyt and formalin smear methods - and their impact on diagnostic accuracy.

Methods: A retrospective study utilized the diagnostic concordance rates between cytology and histology in thyroid FNA of 413 samples using ThinPrep Cytolyt and 283 samples diagnosed by conventional smear techniques. All the FNA’s were performed at the Ziv Medical Center by the same surgeon between 2019 and 2023.

Results: The Cytolyt ThinPrep technique resulted in a significantly lower percentage of nondiagnostic samples (Bethesda 1) compared to the conventional smear technique (2.2% and 14.1% respectively, p< 0.001).

Conclusions: The findings of this study provide valuable insights for otolaryngologists, suggesting that the Cytolyt ThinPrep technique is more effective in reducing nondiagnostic samples and enhancing diagnostic accuracy in thyroid FNA processing. These results can guide clinical decision-making and improve patient outcomes in the evaluation of thyroid nodules.

Presenting Author(s)

Haia Darawshe, MD

otolaryngology resident
Ziv Medical Center
Zefat, HaZafon, Israel

Disclosure(s):
faculty for this accredited education activity has no relationship(s) with ineligible companies to disclose.

Co-Author(s)

AS

Adi Sharabi-Nov

Disclosure information not submitted.

Senior Author(s)

SM

Shlomo Merchavy, MD

HEAD OF THE Head and neck department
Ziv Medical Center Israel
Kfar Tavor, Israel

Disclosure information not submitted.