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Panel Presentations

Rhinology/Allergy

Evaluation and Treatment of Primary Immunoglobulin Deficiency Disorders in Chronic Rhinosinusitis

Sunday, October 12, 2025
4:00 PM - 5:00 PM EDT
Location: 123-124
Disclosure(s):
Chadi A. Makary, MD:

faculty for this accredited education activity has no relationship(s) with ineligible companies to disclose.

Sandra Y. Lin, MD:

faculty for this accredited education activity has no relationship(s) with ineligible companies to disclose.

PROGRAM DESCRIPTION: Primary immunoglobulin deficiency disorders (PIDD) represent a broad spectrum of diseases that can lead to more frequent and more severe infections of the upper airway, mainly chronic rhinosinusitis (CRS) or recurrent acute rhinosinusitis (RARS). PIDD are classified into the following conditions: Common variable immunoglobulin deficiency (CVID), Specific antibody deficiency (SAD), IgG subclass deficiency, selective IgA deficiency. There is clear evidence that prevalence of PIDD is higher in patients with CRS than in the general population. However, many questions remain unanswered. These include what defines difficult-to-treat CRS and when is an evaluation for PIDD warranted in these patients. What is the role of the otolaryngologist in evaluation of PIDD and when is referral to a clinical immunologist warranted? What is the different treatment options for patient with PIDD and CRS?

OUTCOME OBJECTIVE 1: Discuss the evaluation and diagnostic workup of primary immunoglobulin deficiency disorders (PIDD) in patient with rhinosinusitis.

OUTCOME OBJECTIVE 2: Discuss the role of vaccination, prophylaxis antibiotics, and immunoglobulin replacement therapy in patients with PIDD and rhinosinusitis.

OUTCOME OBJECTIVE 3: Discuss the role of endoscopic sinus surgery in patients with PIDD and rhinosinusitis.

BACKGROUND STATEMENT: There is clear evidence that prevalence of primary immunoglobulin deficiency disorders (PIDD) is higher in patients with CRS than in the general population. It is important for otolaryngologists to consider these diseases when dealing with CRS patients.

Comprehensive Otolaryngology Track Statement :

    Moderator(s)

  • CM

    Chadi A. Makary, MD

    Associate Professor
    West Virginia University Dept of Oto
    Morgantown, WV, United States

    Disclosure(s):

    faculty for this accredited education activity has no relationship(s) with ineligible companies to disclose.

    • Panelist(s)

  • SL

    Sandra Y. Lin, MD

    Professor and Chair of Otolaryngology - Head & Neck Surgery
    University of Wisconsin School of Medicine and Public Health
    Madison, WI, United States

    Disclosure(s):

    faculty for this accredited education activity has no relationship(s) with ineligible companies to disclose.

  • JL

    Jivianne T. Lee, MD

    Professor
    UCLA School of Medicine
    Los Angeles, CA, United States

    Disclosure information not submitted.

  • AA

    Antoine E. Azar, MD

    Associate Professor
    Johns Hopkins University
    Baltimore, MD, United States

    Disclosure information not submitted.