A Nomogram Predicting Recurrence for Surgery in Recurrent Nasopharyngeal Carcinoma: A Prospective Real-world Cohort

Tuesday, October 14, 2025

8:06 AM - 8:12 AM EDT

Location: 125

Disclosure(s):

Xiaole Song, MD:

faculty for this accredited education activity has no relationship(s) with ineligible companies to disclose.

Xicai sun, MD, PhD:

faculty for this accredited education activity has no relationship(s) with ineligible companies to disclose.

Introduction: The efficacy of endoscopic nasopharyngectomy in the treatment of recurrent nasopharyngeal carcinoma(rNPC), especially in advanced rNPC, were undetermined. Proper assessment of the recurrence probability of rNPC is crucial for accurately making treatment decisions.

Methods: Pathologically diagnosed rNPC patients of all stages were recruited in a prospective,real world cohort study as the training cohort. All patients underwent the endoscopic nasopharyngectomy. The main and secondary endpoint is overall survival and local recurrence free survival (LRFS) respectively. Clinical records were prospectively collected. Least absolute shrinkage and selection operator (LASSO) penalized Cox regression was conducted for variate selection. A nomogram to measure recurrence probability was created by Cox regression model and validated in a retrospective validating cohort.

Results: 79 rNPC patients has been initially approached for the training cohort, and a total of 53 participants completed the study in the training cohort. 39 patients were included in the validating cohort. In the training cohort, the 6-months, 1-year overall survival rate was 94.3% and 90.2% and the corresponding LRFS rate was 76.6% and 53.4% respectively. Margin, diameter of tumor, immunotherapy, and surgical type were selected as predictive factors for recurrence by Lasso regression. The nomogram based on these four variates showed a favorable discriminatory, predictionary ability, and a wide range of utility in rNPC patients to predict recurrence after endoscopic surgery.

Conclusions: This prospective real-world study indicated that endoscopic surgery was an efficient modality for rNPC treatment.The established nomogram was suitable for predicting probability of local recurrence after endoscopic surgery in rNPC patients.

Presenting Author(s)

Xiaole Song, MD

Director of Mucosal Melanoma Diagnosis and Treatment Center
Eye& ENT Hospital, Fudan University/University of Pennsylvania
Shanghai, Pennsylvania, United States

Disclosure(s):
faculty for this accredited education activity has no relationship(s) with ineligible companies to disclose.
Xicai sun, MD, PhD

Director of Olfactory Neuroblastoma Diagnosis and Treatment Center
Eye& ENT Hospital, Fudan University
Shanghai, United States

Disclosure(s):
faculty for this accredited education activity has no relationship(s) with ineligible companies to disclose.

Co-Author(s)

HZ

Huankang Zhang, PhD

Eye & ENT Hospital, Fudan University, United States

Disclosure information not submitted.
DG

Dantong Gu, MBBS

Eye & ENT Hospital, Fudan University, United States

Disclosure information not submitted.
YL

Yuting Lai, PhD

Eye & ENT Hospital, Fudan University, United States

Disclosure information not submitted.
KX

Kai Xue, PhD

Eye & ENT Hospital, Fudan University, United States

Disclosure information not submitted.
LY

Li Yan, PhD

Eye & ENT Hospital, Fudan University, United States

Disclosure information not submitted.
QL

Quan Liu, PhD

Eye & ENT Hospital, Fudan University, United States

Disclosure information not submitted.

Senior Author(s)

HY

Hongmeng Yu, PhD,MD

Prof
Eye& ENT Hospital, Fudan University, United States

Disclosure information not submitted.