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Scientific Oral Presentations

Laryngology/Broncho-Esophagology

Session: Scientific Oral Presentations 2 - Laryngology/Broncho-Esophagology

Neurogenic Cough: A Systematic Review of Etiologies and Treatment Modalities

Sunday, October 12, 2025

10:18 AM - 10:24 AM EDT

Location: 138

Disclosure(s):

Yara H. Hamdi:

faculty for this accredited education activity has no relationship(s) with ineligible companies to disclose.

Mohamed Farghaly:

faculty for this accredited education activity has no relationship(s) with ineligible companies to disclose.

Introduction: Neurogenic cough, a chronic cough attributed to sensory dysfunction of the vagus nerve, poses a diagnostic and therapeutic challenge. It is often refractory to conventional therapies, leading to significant patient morbidity. While various etiologies and treatment options have been explored, a systematic evaluation of their effectiveness is essential to guide clinical practice.

Methods: A systematic search was conducted across PubMed, Scopus, and Cochrane Library databases for studies published between 2000 and 2023. Inclusion criteria encompassed clinical trials, cohort studies, and case series reporting on neurogenic cough etiologies or treatments. Data extraction and statistical analysis were performed using R, including meta-analysis of treatment outcomes. Python was employed for natural language processing (NLP) to identify emerging themes and trends in etiology classification and therapeutic innovations.

Results: From 1,450 screened studies, 38 met inclusion criteria. Etiologies were predominantly linked to vagal neuropathy (52% of studies) and laryngeal sensory neuropathy (34%). Gabapentin and pregabalin demonstrated the highest efficacy, achieving symptom reduction in 68% of patients, while speech therapy improved cough severity scores by 40%. Python-based NLP revealed a rising focus on neuromodulators (e.g., amitriptyline) and non-invasive vagal nerve stimulation as novel therapies. Heterogeneity in diagnostic criteria and outcome measures limited comparability across studies.

Conclusions: Neurogenic cough management benefits from neuromodulators and targeted speech therapy, though standardized diagnostic criteria are urgently needed. The integration of R and Python enabled robust data synthesis and identified gaps in mechanistic understanding. Future research should prioritize randomized controlled trials to validate emerging therapies and refine etiology-driven treatment algorithms. This review underscores the importance of multidisciplinary approaches to improve patient outcomes in neurogenic cough.

Presenting Author(s)

MF

Mohamed Farghaly

Doctor
Newgiza University
Greensboro, North Carolina, United States

Disclosure(s):
faculty for this accredited education activity has no relationship(s) with ineligible companies to disclose.

Senior Author(s)

ME

Mahmoud M. Elsayed, MD

Neurosurgery Resident and Clinical Researcher
MME Foundation
Mansoura, Egypt

Disclosure information not submitted.

Co-Author(s)

Yara Hamdi, Mrs

Undergraduate student
Badr University in Cairo
Houston , Texas, United States

Disclosure(s):
faculty for this accredited education activity has no relationship(s) with ineligible companies to disclose.
SE

Sherif Elhaig, n/a

Newgiza University, United States

Disclosure information not submitted.
SA

Sara Abozeid

Student
Newgiza University
Giza, Al Jizah, Egypt

Disclosure information not submitted.
KE

Kenzy Elessawy, n/a

Newgiza University, United States

Disclosure information not submitted.
AM

Anas Mohamed

student
Newgiza University
6th of October, Al Jizah, Egypt

Disclosure information not submitted.
HE

Hasnaa Elshazly, MBBCh

Medical intern
Newgiza University
Pyramids Gardens, Al Jizah, Egypt

Disclosure information not submitted.