(A722) Laryngeal Manifestations of Hematologic Malignancies

Introduction: Hematologic malignancies involving the larynx are rare and represent less than 1% of all laryngeal malignancies. Only case series exist to describe the presentation and manifestation of these malignancies. We aim to present 3 distinct cases of lymphoma of the larynx with a review of the current literature.

Methods: This study was a case series. Three cases were reviewed and described along with a review of the current literature.

Results: Our first patient is a 73 year-old male with a history of chronic lymphocytic leukemia (CLL) and presented with chronic progressive laryngeal symptoms was found to have friable and thickened tissues from nasopharynx to glottis which was concerning for infection or manifestation of his known lymphoma, biopsy proved it was CLL. Our second patient is a 70 year-old who presented with a large epiglottic mass requiring awake tracheostomy with no risk factors for squamous cell carcinoma (SCC), at the time of biopsy, the properties of the mass were atypical so many biopsies were taken, flow cytometry revealed diffuse large B-cell lymphoma. Our third patient is a 69-year-old female who presented with dyspnea, stridor, and concern for subglottic stenosis. At the time of biopsy, a proximal tracheal mass was better appreciated, final pathology revealed MALT lymphoma.

Conclusions: Lymphoma should be considered on the differential for patients with painless laryngeal mass or otherwise unexplained mucosal thickening who are older, have a history of hematologic malignancy, and otherwise do not fit the typical profile of a head and neck SCC. This diagnosis is important to consider at the time of biopsy so tissue can appropriately be sent for flow cytometry and expedite treatment.