(A641) The Role of Alcohol Use Disorder in the Management and Outcomes of Hypopharyngeal Malignancy

Introduction: Our study investigates the role of alcohol use disorder (AUD) in the management and outcomes of inpatients with hypopharyngeal malignancy (HM).

Methods: The 2017 National Inpatient Sample (NIS) was queried to identify adult inpatients with a primary diagnosis of hypopharyngeal malignancy (HM) (ICD-10: C12-C13). AUD was identified (ICD-10: F10.1). Univariate and multivariable analyses were performed to identify statistical associations with AUD status.

Results: Of the 1,375 inpatients diagnosed with HM, the majority were male (79.6%), White (67.5%), and had no diagnosis of AUD (84.4%). Mean patient age was 64.6 years. Patients with AUD had a higher incidence of liver disease (20.9% vs. 7.3%), coagulopathy (14.0% vs. 6.5%), preoperative weight loss (55.8% vs. 42.7%), and depression (23.3% vs. 10.8%) than patients without AUD (p < 0.001). On multivariable analyses, adjusting for several patient demographics and comorbidities, patients with AUD had fewer total charges ($109,167 vs. $128,006, p=0.005) than patients without AUD. Patients with and without AUD had similar length of stay (10.09 vs 9.87, p=0.284), number of procedures undergone (5.47 vs. 5.01, p=0.487), time from admission to first procedure (TFP) (1.24 vs. 1.42, p=0.081), and mortality (2.3 vs. 2.6%, p=0.537).

Conclusions: In a national cohort of inpatients with HM, patients with AUD had a higher incidence of many comorbidities and fewer total charges than those without AUD.