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Video

Otology/Neurotology

(A818) Evaluation of Transtympanic and Intratympanic Steroid Injection Dosage in Treatment of Sudden Sensorineural Hearing Loss

Monday, October 13, 2025
12:00 PM - 1:00 PM EDT
Location: OTO EXPO, Posters

    Presenting Author(s)

  • Sanjana Nallapaneni, MPH

    Medical Student
    Northeast Ohio Medical University
    Canfield, Ohio, United States

    • Co-Author(s)

  • Naveen S. Raj

    Medical Student
    Northeast Ohio Medical University
    Rootstown, Ohio, United States

  • MB

    Margaret P. Byars, N/A

    Medical Student
    Northeast Ohio Medical University
    Cincinnati, Ohio, United States

    • Senior Author(s)

  • Anita S. Jeyakumar, MD, MS

    Director Otology and Cochlear Implant Programs
    NEOMED, HEARS, LLC
    Akron, Ohio, United States

Disclosure(s):
Sanjana Nallapaneni, MPH: No relevant relationships to disclose.
Naveen S. Raj: No relevant relationships to disclose.
Margaret P. Byars, N/A: No relevant relationships to disclose.
Anita S. Jeyakumar, MD, MS: No relevant relationships to disclose.


Introduction: Transtympanic steroid injections can help treat sudden sensorineural hearing loss. However, research has not determined the optimal steroid dosage that yields the highest hearing recovery rates.

Methods: IRB approval was obtained. We performed a meta-analysis from September 2024 to January 2025 by using the search terms “transtympanic steroid” and “sensorineural hearing loss” and filters to exclude reviews, systematic reviews, and meta-analyses. We examined dexamethasone and methylprednisolone dosage and hearing recovery.

Results: We reviewed 36 international scientific articles with 3798 total subjects. Gender distribution was 52% males and 48% females. 2.8% (1/36) of our studies used 0.2 mg/mL dexamethasone, 2.8% (1/36) used 2.5 mg/mL dexamethasone, 31% (11/36) used 4 mg/mL dexamethasone, 19% (7/36) used 5 mg/mL dexamethasone, 11% used 8-10 mg/mL dexamethasone, 5.6% (2/36) of used 24 mg/mL dexamethasone, 2.8% (1/36) used 0.3 mg/mL methylprednisolone, 19 % (7/36) used 40 mg/mL methylprednisolone, 2.8% (1/36) used 62.5 mg/mL methylprednisolone, and 6% (2/36) used 100 mg/dl methylprednisolone. 35% (13/36) percent of our studies additionally considered oral prednisone. For the 29 studies that reported hearing recovery in decibels, recoveries ranged from 6.4-41 decibels (dB) with the highest recovery being from a study using 4 mg/mL of dexamethasone.

Conclusions: Wide variability exists in transtympanic steroid injection dosage, with a wide range of outcomes reported. Continued study is needed to determine the optimal steroid combination.