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Video

Head and Neck Surgery

(A521) Charlson-Deyo Comorbidity Index and Overall Survival Following Total Glossectomy for Oral Tongue Squamous Carcinoma

Monday, October 13, 2025
12:00 PM - 1:00 PM EDT
Location: OTO EXPO, Posters

    Presenting Author(s)

  • David Herz, BS

    Medical Student
    Rutgers New Jersey Medical School
    Lyndhurst, New Jersey, United States

    • Co-Author(s)

  • Aman M. Patel, MD

    Resident Physician
    Rutgers New Jersey Medical School
    Newark, New Jersey, United States

  • GB

    George S. Bebawy, BA

    Medical Student
    Rutgers New Jersey Medical School
    newark, NJ, United States

  • Afash Haleem, BA

    Medical Student
    Rutgers New Jersey Medical School
    Newark, NJ, United States

  • AF

    Andrey Filimonov, MD, PharmD

    Assistant Professor
    Rutgers New Jersey Medical School
    Newark, New Jersey, United States

    • Senior Author(s)

  • Ghayoour S. Mir, DO

    Assistant Professor
    Rutgers New Jersey Medical School
    Newark, NJ, United States

Disclosure(s):
David Herz, BS: No relevant relationships to disclose.
Aman M. Patel, MD: No relevant relationships to disclose.
George S. Bebawy, BA: No relevant relationships to disclose.
Andrey Filimonov, MD, PharmD: No relevant relationships to disclose.


Introduction: Charlson-Deyo Comorbidity Index (CCI) predicts ten-year mortality for a patient based on a range of comorbid conditions. Objective preoperative risk assessment tools may inform physician and patient decision making. Our study examines the relationship between CCI and overall survival (OS) following total glossectomy for oral tongue squamous cell carcinoma (OTSCC).

Methods: A retrospective analysis of the 2004-2016 National Cancer Database (NCDB) was conducted to extract adult patients with pT1-4 N0-3 M0 OTSCC undergoing total glossectomy. Kaplan-Meier survival analysis and Cox-Proportional Hazards modeling were used to analyze the impact of increasing CCI on OS.

Results: Of the 1,839 patients satisfying inclusion criteria, 1,412 (77%) were CCI=0, 330 (18%) were CCI=1, and 97 (5%) were CCI=2+. On univariate analysis, CCI groups differed by age (27% were ≥65 years old in CCI=0 vs 35% and 47% in CCI groups 1 and 2+ respectively, p< 0.001) and systemic therapy (p=0.003). There was no significant difference between CCI groups in sex, race, T-stage, N-stage, margin status, primary site, radiation therapy, or systemic therapy. On Kaplan-Meier analysis 5-year OS for CCI=0, CCI=1, and CCI=2+ was 38.6%, 35.9%, and 27.4%, respectively (p < 0.001). CCI=1 (HR 1.11, 95% CI 0.88-1.38, p=0.379) was not associated with worse OS than CCI=0. CCI=2+ (HR 1.69, 95% CI 1.17-2.42, p=0.005) was associated with worse OS than CCI=0.

Conclusions: In a cohort of adult patients with pT1-4 N0-3 M0 OTSCC undergoing total glossectomy, CCI=2+ was associated with worse OS. During preoperative and postoperative counseling, CCI should be optimized and considered as a factor influencing survival outcomes.